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2023年3月11日 星期六

Patient FAQ: Can Antihypertensive Medications Cause Erectile Dysfunction?

 

"Doctor, I seemed to have erectile dysfunction since I started hypertension treatment with antihypertensive drugs. Are they related?”

First of all, the answer may be yes or no.

Why is that?

 

First, we need to know some background knowledge.

“Erectile dysfunction is a precursor to circulatory (cardiovascular) problems!"

The caliber of the male genital arteries is the smallest in the entire body, even smaller than the coronary arteries that supply the heart!

Therefore, if the blood vessels begin to harden and narrow, “erectile dysfunction will occur earlier than myocardial infarction!"

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So, men must not neglect erectile dysfunction. Your “buddy” may be your health sentinel and lifesaver!

In practice, urology clinics also often detect other systemic diseases through erectile dysfunction, such as hypertension, hyperlipidemia, diabetes, endocrine diseases, etc.

Therefore, "having hypertension itself means that there is a high possibility and risk of erectile dysfunction!"

Therefore, erectile dysfunction in hypertensive patients is likely to be a problem with the disease itself, rather than medication!

 

Furthermore, erectile dysfunction has many risk factors, including the three highs, endocrine problems mentioned earlier, as well as many other risk factors such as smoking, alcoholism, obesity, sedentary lifestyle, age, sleep disorders, neurological diseases, prostate diseases, liver and kidney dysfunction, the influence of other drugs, social and psychological problems, and partner relationship issues, etc.

In other words, "there are many other possible factors that cause sexual dysfunction!"

 

Finally, does antihypertensive medication itself affect sexual dysfunction?

The answer is: most of them won't, but some will!

For example, some diuretics and non-selective beta-blockers may indeed have an impact on sexual function.

(Special note: Medications that help with urination, smooth urine flow, and treat prostate enlargement are not diuretics! Many patients misunderstand this, so it is emphasized here!)

However, with the advancement of technology, the choice of antihypertensive drugs is increasing.

Even if a certain type of medication must be used, it may be possible to find a replacement drug in the same category.

For example, when a β-blocker is required due to the condition, Nebivolol (Nebilet®), a new generation selective β1-blocker, can be chosen.

Not only does it not cause erectile dysfunction, it may even be helpful!


Therefore, if you are worried that blood pressure medication may affect sexual function, you can discuss with your cardiologist.

More importantly, you must examine whether your chronic diseases, such as hypertension and diabetes, are well controlled and whether there are other risk factors causing sexual dysfunction.

Because these factors not only affect one’s sexual life, but also relate to one's health and even life safety!

 


 

Special thanks: I am grateful to my nice classmate, Dr. Cheng-Yen Chuang from the Cardiology Department at Shin Kong Wu Ho-Su Memorial Hospital, for providing hypertension treatment information!



Reference: https://www.mdpi.com/2227-9059/9/4/432

 

https://www.mayoclinic.org/diseases-conditions/erectile-dysfunction/symptoms-causes/syc-20355776

 

https://pubmed.ncbi.nlm.nih.gov/16491268/

 

https://jtp.taiwan-pharma.org.tw/151/048-053.html

門診日常:血壓藥會影響性功能嗎?

 

“醫生,我覺得自從知道有高血壓、開始吃血壓藥控制以後,那方面比較不行耶,血壓藥是不是對那個有影響?”

 

先說結論 可能是 也可能不是

 

為什麼這麼說呢?

 

 

首先,我們要知道一個背景知識

 

「男性性功能障礙是循環(心血管)問題的前兆!」

 

男性生殖器的動脈口徑

 

是全身動脈中尺寸最小的

 

甚至比供應心臟的冠狀動脈更小!

 

因此 若血管開始產生硬化、狹窄

 

「性功能障礙會比心肌梗塞還要早發生!」

 

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所以男性千萬不要輕忽性功能障礙

 

您的好兄弟很可能是您的健檢哨兵、救命恩人!

 

實務上

 

泌尿科門診也常藉由性功能障礙發現其他全身性疾病

 

如高血壓、高血脂、糖尿病、內分泌疾病...等等

 

因此 「有高血壓這件事本身就代表有性功能障礙的可能性與風險極高!

 

所以 高血壓患者有性功能障礙 很有可能是疾病本身的問題 而不是藥物!

 

 

再者 性功能障礙有很多危險因子

 

除了前面提到的三高、內分泌問題

 

還有其他諸多危險因子如抽菸、酗酒、肥胖、久坐、年齡、睡眠障礙、神經系統疾病、攝護腺疾病、肝腎功能不佳、其他藥物影響、社會心理問題、伴侶關係問題...等等

 

也就是說

 

「還有很多其他可能因素是造成性功能障礙的元兇!」

 

 

最後 血壓藥本身是否對性功能障礙有影響?

 

答案是:大部份不會 但有些會!

 

比如某些利尿劑、非選擇性乙型腎上腺素阻斷劑 (non-selective β-blockers)

 

的確有可能對性功能造成影響

 

(特別備註:幫助排尿、讓小便順利、治療攝護腺肥大...等藥物,並不是利尿劑!很多病患有誤解,特別聲明!)

 

但是

 

隨著科技的進步

 

高血壓藥物選擇也越來越多

 

即使必須使用某類藥物、也有可能在同種類找到替代藥物

 

比如因病情需要得使用乙型腎上腺素阻斷劑時

 

有新一代選擇性乙型腎上腺素阻斷劑(selective β1-blockers) Nebivolol (Nebilet®)可以選擇

 

不僅不影響性功能 甚至可能對性功能有幫助!

 

 

因此

 

若擔心血壓藥影響性功能

 

不妨與您的心臟科醫師討論

 

更重要的是

 

一定要審視自己高血壓、糖尿病...等慢性病是否控制良好

 

以及是否有其他造成性功能障礙的危險因子

 

因為這些因素

 

不僅僅關係到性生活的協調

 

更關係到自己的健康甚至生命安全喔!

 

 

 

後記:有關血壓藥的知識,得感謝我的好同學─新光醫院心臟科莊正彥醫師提供相關訊息!

 

 


參考資料:https://www.mdpi.com/2227-9059/9/4/432

 

https://www.mayoclinic.org/diseases-conditions/erectile-dysfunction/symptoms-causes/syc-20355776

 

https://pubmed.ncbi.nlm.nih.gov/16491268/

 

https://jtp.taiwan-pharma.org.tw/151/048-053.html